Pharmacodynamics of macrolides, azalides, and streptogramins: effect on extracellular pathogens.

Rational Dosing of Antimicrobial Agents for Bovine Respiratory Disease: The Use of Plasma Versus Tissue Concentrations in Predicting Efficacy

Factors associated with identifying an appropriate dose and dosing regimen for the treatment of bovine respiratory disease include the activity of a given drug against common respiratory bacterial pathogens and the ability of the drug to gain access to the site of infection. Although randomized prospective field trials are the best means of determining the relative efficacy of antimicrobial age...

Comparison of charcoal- and starch-based media for testing susceptibilities of Legionella species to macrolides, azalides, and fluoroquinolones.

We compared growth characteristics of 46 Legionella strains grown on buffered charcoal yeast extract alpha (BCYE alpha) agar and buffered starch yeast extract (BSYE) agar and MICs of macrolides, azalides, and fluoroquinolones for these organisms. Growth was poor and not reproducible on BSYE agar. Growth was excellent on BCYE alpha, and MICs were easy to interpret. BCYE alpha is superior to BSYE...

The in vitro profile of selected 14-membered azalides.

The in vitro antimicrobial potency of 10-aza-9-deoxo-11-deoxyerythromycin A, the first member of a new class of macrolide antibiotic, was determined. Several other members of this family of azalide were prepared and similarly screened in order to begin to define the antibiotic potential of the class. The results indicate that the SAR for this structural type parallels that of other macrolides a...

Mutation in 23S rRNA responsible for resistance to 16-membered macrolides and streptogramins in Streptococcus pneumoniae.

Streptococcus pneumoniae clinical isolate BM4455 was resistant to 16-membered macrolides and to streptogramins. This unusual resistance phenotype was due to an A(2062)C (Escherichia coli numbering) mutation in domain V of the four copies of 23S rRNA.

Reflection paper on the use of macrolides, lincosamides and streptogramins in food-producing animals